Sandbox Reserved 474

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==Your Heading Here (maybe something like 'Structure')==<StructureSection load='1gnh' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>'''C-Reactive Protein''' (CRP) consists of five identical, non-covalently associated protomers that are arranged in a symmetrical fashion weighing ~ 23kDa as it participates in the systemic response to inflammation. CRP acts as a recognition molecule such that it binds specifically to certain molecular configurations either during cell death or on the surface of exposed pathogens. After an acute inflammatory stimulus, CRP is synthesized by hepatocytes. CRP sits on the short arm of chromosome 1 (in humans) and it contains only one intron and it is regulated at the transcriptional level by '''cytokine interleukin-6''' (IL-6) and by '''interleukin-1β''' (IL-1β). Both IL-6 and IL-1β control expression of many acute phase protein genes through activation of several transcription factors including STAT3, C/EBP family members and Rel proteins (NF-κB).
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==Your Heading Here (maybe something like 'Structure')==<StructureSection load='1gnh' size='500' side='right' caption='Structure of Human C-Reactive Protein (PDB entry [[1gnh]])' scene=''>'''C-Reactive Protein''' (CRP) consists of five identical, non-covalently associated protomers that are arranged in a symmetrical fashion weighing ~ 23kDa as it participates in the systemic response to inflammation. CRP acts as a recognition molecule such that it binds specifically to certain molecular configurations either during cell death or on the surface of exposed pathogens. After an acute inflammatory stimulus, CRP is synthesized by hepatocytes. CRP sits on the short arm of chromosome 1 (in humans) and it contains only one intron and it is regulated at the transcriptional level by '''cytokine interleukin-6''' (IL-6) and by '''interleukin-1β''' (IL-1β). Both IL-6 and IL-1β control expression of many acute phase protein genes through activation of several transcription factors including STAT3, C/EBP family members and Rel proteins (NF-κB).
Some of the biological effects/functions of CRP include: CRP's unique ability to only bind to phosphocholine ligands of either damaged or apoptotic cells. Additionally, CRP can bind to other ligands such as phosphoethanolamine, chromatin, histones, fibronectin, small nuclear ribonucleoproteins, laminin, and polycations. CRP also contains pleiotropic effects which produce both pro and anti-inflammatory responses.</StructureSection><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->
Some of the biological effects/functions of CRP include: CRP's unique ability to only bind to phosphocholine ligands of either damaged or apoptotic cells. Additionally, CRP can bind to other ligands such as phosphoethanolamine, chromatin, histones, fibronectin, small nuclear ribonucleoproteins, laminin, and polycations. CRP also contains pleiotropic effects which produce both pro and anti-inflammatory responses.</StructureSection><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->

Revision as of 19:14, 30 April 2012

==Your Heading Here (maybe something like 'Structure')==

Structure of Human C-Reactive Protein (PDB entry 1gnh)

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This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Structure and Function

CRPs five promoter structures are folded into two anti-parallel β-sheets with flattened jellyroll topologies. Each promoter contains a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket.

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