Sandbox Reserved 481

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== Introduction ==
== Introduction ==
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'''Cholix toxin''' is a type of exotoxin which is derived from the bacteria [[Vibrio Cholerae]]. It belongs to the class of proteins called enzymes whose main function is to act as a catalyst from chemical reactions within living organisms.
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'''Cholix toxin'''from the bacteria ''Vibrio Cholerae''inactivates eukaryotic elongation factor 2 by transferring ADP-ribose from NAD+ <1> through the enzyme ADP-riboyltransferase. The cholix toxin has been known to cause disease in both plants and animals <2>. Specifically, the toxin can cause diptheria, cholera, and whooping cough <2>.
== Structure ==
== Structure ==
<Structure load='2q5t' size='500' frame='true' align='center' caption='Insert caption here' scene='Insert optional scene name here' />
<Structure load='2q5t' size='500' frame='true' align='center' caption='Insert caption here' scene='Insert optional scene name here' />
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== Medical Implications or Possible Applications ==
== Medical Implications or Possible Applications ==
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== References ==
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1. The 1.8A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic Model

Revision as of 22:53, 30 April 2012

This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Contents

Introduction

Cholix toxinfrom the bacteria Vibrio Choleraeinactivates eukaryotic elongation factor 2 by transferring ADP-ribose from NAD+ <1> through the enzyme ADP-riboyltransferase. The cholix toxin has been known to cause disease in both plants and animals <2>. Specifically, the toxin can cause diptheria, cholera, and whooping cough <2>.

Structure

Insert caption here

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Mechanism of Action

Medical Implications or Possible Applications

References

1. The 1.8A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic Model

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