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For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia Tubulin

Introduction

Tubulin is a globular protein. The most common types of tubulin are alpha and beta tubulin. Its main function is to create microtubules. The alpha and beta proteins polymerize to create the microtubule. Gama Tubulin is also an important tubulin protein. Tubulin is used in plants as well as animals. For plants, it is important for acentrosomal microtubule nucleation in plants. This can be shown in Arabidopsis. The gama tubulin protein binds with other proteins in order to create a “cap” at the negative end of the microtubule and acts as a scaffold for the alpha/beta tubulin dimer to polymerize.

Microtubules are important for maintaining cell structure, providing platforms for intracellular transport, forming the spindle during mitosis, as well as other cellular processes. Many viruses such as gemini-viruses can attack these proteins and cause cell death which leads to plant death. One particular study by Keech et al showed that Cabbage Leaf Curl Virus (CaLCuV) induced senescence in Arabidopsis plants which lead to plant death.

Structure

Mechanism of Action

Medical Implications or Possible Applications

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