1onq
From Proteopedia
(New page: 200px<br /> <applet load="1onq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1onq, resolution 2.15Å" /> '''Crystal Structure o...) |
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caption="1onq, resolution 2.15Å" /> | caption="1onq, resolution 2.15Å" /> | ||
'''Crystal Structure of CD1a in Complex with a Sulfatide'''<br /> | '''Crystal Structure of CD1a in Complex with a Sulfatide'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ONQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FUC, NAG and SLF as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1ONQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=SLF:'>SLF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-glycolipid complex]] | [[Category: protein-glycolipid complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:34:36 2008'' |
Revision as of 14:34, 15 February 2008
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Crystal Structure of CD1a in Complex with a Sulfatide
Contents |
Overview
CD1 antigens bind a variety of self and foreign lipid and glycolipid, antigens for presentation to CD1-restricted T cell receptors (TCRs). Here, we report the crystal structure of human CD1a in complex with a sulfatide, self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped, conformation, with the sphingosine chain completely buried in the A', pocket and the fatty acid chain emerging from the interface of the A', pocket into the more exposed F' pocket. The headgroup is anchored in the, A'-F' junction and protrudes into the F' pocket for TCR recognition., Because the A' pocket is narrow with a fixed terminus, it can act as a, molecular 'ruler' to select alkyl chains of a particular length.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1ONQ is a Protein complex structure of sequences from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A., Zajonc DM, Elsliger MA, Teyton L, Wilson IA, Nat Immunol. 2003 Aug;4(8):808-15. Epub 2003 Jun 29. PMID:12833155
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