2bji
From Proteopedia
(New page: 200px<br /> <applet load="2bji" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bji, resolution 1.24Å" /> '''HIGH RESOLUTION STR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BJI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BJI OCA]]. | + | 2BJI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BJI OCA]]. |
==Reference== | ==Reference== | ||
High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy., Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, Cooper J, Gore M, Wood S, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):545-55. Epub 2005, Apr 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15858264 15858264] | High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy., Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, Cooper J, Gore M, Wood S, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):545-55. Epub 2005, Apr 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15858264 15858264] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Inositol-phosphate phosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Badyal, R.]] | [[Category: Badyal, R.]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:12:31 2007'' |
Revision as of 11:07, 30 October 2007
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HIGH RESOLUTION STRUCTURE OF MYO-INOSITOL MONOPHOSPHATASE, THE TARGET OF LITHIUM THERAPY
Overview
Inositol monophosphatase is a key enzyme of the phosphatidylinositol, signalling pathway and the putative target of the mood-stabilizing drug, lithium. The crystal structure of bovine inositol monophosphatase has been, determined at 1.4 A resolution in complex with the physiological magnesium, ion ligands. Three magnesium ions are octahedrally coordinated at the, active site of each of the two subunits of the inositol monophosphatase, dimer and a detailed three-metal mechanism is proposed. Ligands to the, three metals include the side chains of Glu70, Asp90, Asp93 and Asp220, the backbone carbonyl group of Ile92 and several solvent molecules, including the proposed nucleophilic water molecule (W1) ligated by both, Mg-1 and Mg-3. Modelling of the phosphate moiety of inositol monophosphate, ... [(full description)]
About this Structure
2BJI is a [Single protein] structure of sequence from [Bos taurus] with MG as [ligand]. Active as [Inositol-phosphate phosphatase], with EC number [3.1.3.25]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy., Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, Cooper J, Gore M, Wood S, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):545-55. Epub 2005, Apr 20. PMID:15858264
Page seeded by OCA on Tue Oct 30 13:12:31 2007
