1p4u
From Proteopedia
(New page: 200px<br /> <applet load="1p4u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p4u, resolution 2.20Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1p4u. | + | [[Image:1p4u.jpg|left|200px]]<br /><applet load="1p4u" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1p4u, resolution 2.20Å" /> | caption="1p4u, resolution 2.20Å" /> | ||
'''CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE'''<br /> | '''CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1P4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4U OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein transport]] | [[Category: protein transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:38:49 2008'' |
Revision as of 14:38, 15 February 2008
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CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE
Overview
Adaptor proteins load transmembrane protein cargo into transport vesicles, and serve as nexuses for the formation of large multiprotein complexes on, the nascent vesicles. The gamma-adaptin ear (GAE) domains of the AP-1, adaptor protein complex and the GGA adaptor proteins recruit accessory, proteins to these multiprotein complexes by binding to a hydrophobic, motif. We determined the structure of the GAE domain of human GGA3 in, complex with a peptide based on the DFGPLV sequence of the accessory, protein Rabaptin-5 and refined it at a resolution of 2.2 A. The leucine, and valine residues of the peptide are partly buried in two contiguous, shallow, hydrophobic depressions. The anchoring phenylalanine is buried in, a deep pocket formed by the aliphatic portions of two conserved arginine, residues, along with an alanine and a proline, illustrating the unusual, function of a cluster of basic residues in binding a hydrophobic motif.
About this Structure
1P4U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3., Miller GJ, Mattera R, Bonifacino JS, Hurley JH, Nat Struct Biol. 2003 Aug;10(8):599-606. PMID:12858162
Page seeded by OCA on Fri Feb 15 16:38:49 2008
