1p57
From Proteopedia
(New page: 200px<br /> <applet load="1p57" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p57, resolution 1.75Å" /> '''Extracellular domai...) |
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| - | [[Image:1p57. | + | [[Image:1p57.jpg|left|200px]]<br /><applet load="1p57" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1p57" size=" | + | |
caption="1p57, resolution 1.75Å" /> | caption="1p57, resolution 1.75Å" /> | ||
'''Extracellular domain of human hepsin'''<br /> | '''Extracellular domain of human hepsin'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P57 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CR4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1P57 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CR4:'>CR4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P57 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: srcr]] | [[Category: srcr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:38:52 2008'' |
Revision as of 14:38, 15 February 2008
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Extracellular domain of human hepsin
Overview
Hepsin is an integral membrane protein that may participate in cell growth, and in maintaining proper cell morphology and is overexpressed in a number, of primary tumors. We have determined the 1.75 A resolution structure of, the extracellular component of human hepsin. This structure includes a, 255-residue trypsin-like serine protease domain and a 109-residue region, that forms a novel, poorly conserved, scavenger receptor cysteine-rich, (SRCR) domain. The two domains are associated with each other through a, single disulfide bond and an extensive network of noncovalent, interactions. The structure suggests how the extracellular region of, hepsin may be positioned with respect to the plasma membrane.
About this Structure
1P57 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain., Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA, Structure. 2003 Sep;11(9):1123-31. PMID:12962630
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