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1p7q
From Proteopedia
(New page: 200px<br /> <applet load="1p7q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p7q, resolution 3.40Å" /> '''Crystal Structure o...) |
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| - | [[Image:1p7q. | + | [[Image:1p7q.jpg|left|200px]]<br /><applet load="1p7q" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1p7q" size=" | + | |
caption="1p7q, resolution 3.40Å" /> | caption="1p7q, resolution 3.40Å" /> | ||
'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor'''<br /> | '''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P7Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1P7Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7Q OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hla-a2/lir-1 complex]] | [[Category: hla-a2/lir-1 complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:10 2008'' |
Revision as of 14:39, 15 February 2008
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Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor
Contents |
Overview
Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor, expressed on monocytes, dendritic cells and lymphocytes, regulates, cellular function by binding a broad range of classical and nonclassical, major histocompatibility complex (MHC) class I molecules, and the human, cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A, crystal structure of a complex between the LIR-1 D1D2 domains and the MHC, class I molecule HLA-A2. LIR-1 contacts the mostly conserved, beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site, comprises residues at the interdomain hinge, and a patch at the D1 tip., The structure shows how LIR-1 recognizes UL18 and diverse MHC class I, molecules, and indicates that a similar mode of MHC class I recognition is, used by other LIR family members.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1P7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:12897781
Page seeded by OCA on Fri Feb 15 16:39:10 2008
