1p8z
From Proteopedia
(New page: 200px<br /> <applet load="1p8z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p8z, resolution 2.60Å" /> '''Complex Between Rab...) |
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| - | [[Image:1p8z. | + | [[Image:1p8z.jpg|left|200px]]<br /><applet load="1p8z" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1p8z, resolution 2.60Å" /> | caption="1p8z, resolution 2.60Å" /> | ||
'''Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156'''<br /> | '''Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P8Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with CD, CA and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1P8Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=CD:'>CD</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: linker between gelsolin domain 1 and domain 2]] | [[Category: linker between gelsolin domain 1 and domain 2]] | ||
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Revision as of 14:39, 15 February 2008
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Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156
Contents |
Overview
We present the 2.6 A resolution crystal structure of a complex formed, between G-actin and gelsolin fragment Met25-Gln160 (G1+). The structure, differs from those of other gelsolin domain 1 (G1) complexes in that an, additional six amino acid residues from the crucial linker region into, gelsolin domain 2 (G2) are visible and are attached securely to the, surface of actin. The linker segment extends away from G1 up the face of, actin in a direction that infers G2 will bind along the same long-pitch, helical strand as the actin bound to G1. This is consistent with a, mechanism whereby G2 attaches gelsolin to the side of a filament and then, directs G1 toward a position where it would disrupt actin-actin contacts., Alignment of the sequence of the structurally important residues within, the G1-G2 linker with those of WH2 (WASp homology domain 2) domain protein, family members (e.g. WASp (Wiscott-Aldridge syndrome protein) and thymosin, beta4) suggests that the opposing activities of filament assembly and, disassembly may exploit a common patch on the surface of actin.
Disease
Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]
About this Structure
1P8Z is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus with , and as ligands. Full crystallographic information is available from OCA.
Reference
From the first to the second domain of gelsolin: a common path on the surface of actin?, Irobi E, Burtnick LD, Urosev D, Narayan K, Robinson RC, FEBS Lett. 2003 Sep 25;552(2-3):86-90. PMID:14527665
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