1p9o
From Proteopedia
(New page: 200px<br /> <applet load="1p9o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p9o, resolution 2.30Å" /> '''Crystal Structure o...) |
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caption="1p9o, resolution 2.30Å" /> | caption="1p9o, resolution 2.30Å" /> | ||
'''Crystal Structure of Phosphopantothenoylcysteine Synthetase'''<br /> | '''Crystal Structure of Phosphopantothenoylcysteine Synthetase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P9O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphopantothenate--cysteine_ligase Phosphopantothenate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.5 6.3.2.5] Full crystallographic information is available from [http:// | + | 1P9O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphopantothenate--cysteine_ligase Phosphopantothenate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.5 6.3.2.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: synthetase]] | [[Category: synthetase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:29 2008'' |
Revision as of 14:39, 15 February 2008
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Crystal Structure of Phosphopantothenoylcysteine Synthetase
Overview
The structure of human phosphopantothenoylcysteine (PPC) synthetase was, determined at 2.3 A resolution. PPC synthetase is a dimer with identical, monomers. Some features of the monomer fold resemble a group of, NAD-dependent enzymes, while other features resemble the ribokinase fold., The ATP, phosphopantothenate, and cysteine binding sites were deduced from, modeling studies. Highly conserved ATP binding residues include Gly43, Ser61, Gly63, Gly66, Phe230, and Asn258. Highly conserved, phosphopantothenate binding residues include Asn59, Ala179, Ala180, and, Asp183 from one monomer and Arg55' from the adjacent monomer. The, structure predicts a ping pong mechanism with initial formation of an, acyladenylate intermediate, followed by release of pyrophosphate and, attack by cysteine to form the final products PPC and AMP.
About this Structure
1P9O is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Phosphopantothenate--cysteine ligase, with EC number 6.3.2.5 Full crystallographic information is available from OCA.
Reference
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution., Manoj N, Strauss E, Begley TP, Ealick SE, Structure. 2003 Aug;11(8):927-36. PMID:12906824
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