1pbh
From Proteopedia
(New page: 200px<br /> <applet load="1pbh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pbh, resolution 3.2Å" /> '''CRYSTAL STRUCTURE OF...) |
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caption="1pbh, resolution 3.2Å" /> | caption="1pbh, resolution 3.2Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] Full crystallographic information is available from [http:// | + | 1PBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: thiol protease]] | [[Category: thiol protease]] | ||
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Revision as of 14:39, 15 February 2008
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CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION
Overview
A wild-type human procathepsin B was expressed, crystallized in two, crystal forms and its crystal structure determined at 3.2 and 3.3, Angstroms resolution. The structure reveals that the propeptide folds on, the cathepsin B surface, shielding the enzyme active site from exposure to, solvent. The structure of the enzymatically active domains is virtually, identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are, lifted above the body of the mature enzyme, supporting the propeptide, structure.
About this Structure
1PBH is a Single protein structure of sequence from Homo sapiens. Active as Cathepsin B, with EC number 3.4.22.1 Full crystallographic information is available from OCA.
Reference
Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide., Turk D, Podobnik M, Kuhelj R, Dolinar M, Turk V, FEBS Lett. 1996 Apr 22;384(3):211-4. PMID:8617355
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