1pdg
From Proteopedia
(New page: 200px<br /> <applet load="1pdg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pdg, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF...) |
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caption="1pdg, resolution 3.0Å" /> | caption="1pdg, resolution 3.0Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PDG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1PDG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: growth factor]] | [[Category: growth factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:53 2008'' |
Revision as of 14:39, 15 February 2008
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CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Contents |
Overview
The crystal structure of the homodimeric BB isoform of human recombinant, platelet-derived growth factor (PDGF-BB) has been determined by X-ray, analysis to 3.0 A resolution. The polypeptide chain is folded into two, highly twisted antiparallel pairs of beta-strands and contains an unusual, knotted arrangement of three intramolecular disulfide bonds. Dimerization, leads to the clustering of three surface loops at each end of the, elongated dimer, which most probably form the receptor recognition sites.
Disease
Known diseases associated with this structure: Dermatofibrosarcoma protuberans OMIM:[190040], Giant-cell fibroblastoma OMIM:[190040], Meningioma, SIS-related OMIM:[190040]
About this Structure
1PDG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human platelet-derived growth factor BB., Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M, EMBO J. 1992 Nov;11(11):3921-6. PMID:1396586
Page seeded by OCA on Fri Feb 15 16:39:53 2008
