1pdr
From Proteopedia
(New page: 200px<br /> <applet load="1pdr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pdr, resolution 2.8Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1pdr. | + | [[Image:1pdr.jpg|left|200px]]<br /><applet load="1pdr" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1pdr, resolution 2.8Å" /> | caption="1pdr, resolution 2.8Å" /> | ||
'''CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN'''<br /> | '''CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PDR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1PDR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:56 2008'' |
Revision as of 14:39, 15 February 2008
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CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN
Overview
PDZ domains (also known as DHR domains or GLGF repeats) are approximately, 90-residue repeats found in a number of proteins implicated in ion-channel, and receptor clustering, and the linking of receptors to effector enzymes., PDZ domains are protein-recognition modules; some recognize proteins, containing the consensus carboxy-terminal tripeptide motif S/TXV with high, specificity. Other PDZ domains form homotypic dimers: the PDZ domain of, the neuronal enzyme nitric oxide synthase binds to the PDZ domain of, PSD-95, an interaction that has been implicated in its synaptic, association. Here we report the crystal structure of the third PDZ domain, of the human homologue of the Drosophila discs-large tumour-suppressor, gene product, DlgA. It consists of a five-stranded antiparallel, beta-barrel flanked by three alpha-helices. A groove runs over the surface, of the domain, ending in a conserved hydrophobic pocket and a buried, arginine; we suggest that this is the binding site for the C-terminal, peptide.
About this Structure
1PDR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a PDZ domain., Morais Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, Marfatia SM, Chishti AH, Liddington RC, Nature. 1996 Aug 15;382(6592):649-52. PMID:8757139
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