Sandbox Reserved 480
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<Structure load='2pah' size='400' frame='true' align='right' caption='Phenylalanine Hydroxylase' scene='Insert optional scene name here'/> | <Structure load='2pah' size='400' frame='true' align='right' caption='Phenylalanine Hydroxylase' scene='Insert optional scene name here'/> | ||
| - | Phenylalanine Hydroxylase (PheOH) is a type of enzyme involved in the catalization of [http://en.wikipedia.org/wiki/Phenylalanine phenylalanine] into [http://en.wikipedia.org/wiki/Tyrosine tyrosine].It belongs to the family of tetrahydrobiopterin (BH4) dependent aromatic amino acid hydrolase family of proteins. Some other enzymes in this family include tyrosine hydroxylase and tryptophan hydroxylase. Below is a small scale phylogenetic tree of the different enzymes in this family. The human phenylalanine hydroxylase is labeled here as PH4H_HUMAN/119-450. | + | Phenylalanine Hydroxylase (PheOH) is a type of enzyme involved in the catalization of [http://en.wikipedia.org/wiki/Phenylalanine phenylalanine] into [http://en.wikipedia.org/wiki/Tyrosine tyrosine].It belongs to the family of tetrahydrobiopterin (BH4) dependent aromatic amino acid hydrolase family of proteins.<ref name="BH4_H">PMID: 14640675<ref/> Some other enzymes in this family include tyrosine hydroxylase and tryptophan hydroxylase. Below is a small scale phylogenetic tree of the different enzymes in this family. The human phenylalanine hydroxylase is labeled here as PH4H_HUMAN/119-450. |
[[Image:Phylogenetic_tree_BH4_H.gif]] | [[Image:Phylogenetic_tree_BH4_H.gif]] | ||
These enzymes add a hydroxyl group to the side chain of their corresponding amino acid. In order for this reaction to occur they are all dependent on BH4, as it acts as an electron carrier for the reaction. BH4 dependent aromatic amino acid hydroxylases are found in eukaryotic and some bacteria cells. In mammals PheOH is found mostly in the liver, where it can breakdown excess Phe from the diet. Mutations in this enzyme can lead to phenylketonuria (PKU), where phenylalanine builds up in the body and can cause mental retardation. Hyperphenylalaninemia is a similar disorder, which also involves a disruption in the metabolic pathway of Phe. | These enzymes add a hydroxyl group to the side chain of their corresponding amino acid. In order for this reaction to occur they are all dependent on BH4, as it acts as an electron carrier for the reaction. BH4 dependent aromatic amino acid hydroxylases are found in eukaryotic and some bacteria cells. In mammals PheOH is found mostly in the liver, where it can breakdown excess Phe from the diet. Mutations in this enzyme can lead to phenylketonuria (PKU), where phenylalanine builds up in the body and can cause mental retardation. Hyperphenylalaninemia is a similar disorder, which also involves a disruption in the metabolic pathway of Phe. | ||
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== References == | == References == | ||
| + | <references /> | ||
Revision as of 00:59, 3 May 2012
| This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500. | ||||||
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More help: Help:Editing For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia Phenylalanine Hydroxylase
Phenylalanine Hydroxylase (PheOH) is a type of enzyme involved in the catalization of phenylalanine into tyrosine.It belongs to the family of tetrahydrobiopterin (BH4) dependent aromatic amino acid hydrolase family of proteins.[1] |
