1q6k
From Proteopedia
(New page: 200px<br /> <applet load="1q6k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q6k, resolution 2.1Å" /> '''Cathepsin K complexe...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1q6k. | + | [[Image:1q6k.jpg|left|200px]]<br /><applet load="1q6k" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1q6k" size=" | + | |
caption="1q6k, resolution 2.1Å" /> | caption="1q6k, resolution 2.1Å" /> | ||
'''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate'''<br /> | '''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1Q6K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and TCO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http:// | + | 1Q6K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=TCO:'>TCO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6K OCA]. |
==Reference== | ==Reference== | ||
| Line 33: | Line 32: | ||
[[Category: catk]] | [[Category: catk]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:42:54 2008'' |
Revision as of 14:42, 15 February 2008
|
Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
Contents |
Overview
The synthesis and biological activity of a series of aldehyde inhibitors, of cathepsin K are reported. Exploration of the properties of the S(1), subsite with a series of alpha-amino aldehyde derivatives substituted at, the P(1) position afforded compounds with cathepsin K IC(50)s between 52, microM and 15 nM.
Disease
Known disease associated with this structure: Pycnodysostosis OMIM:[601105]
About this Structure
1Q6K is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.
Reference
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342
Page seeded by OCA on Fri Feb 15 16:42:54 2008
Categories: Cathepsin K | Homo sapiens | Single protein | Catalano, J.G. | Deaton, D.N. | Furfine, E.S. | Hassell, A.M. | McFadyen, R.B. | Miller, A.B. | Miller, L.R. | Shewchuk, L.M. | Willard, D.H. | Wright, L.L. | SO4 | TCO | Cathepsin k | Catk
