1q9o
From Proteopedia
(New page: 200px<br /> <applet load="1q9o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q9o, resolution 1.79Å" /> '''S45-18 Fab Unligand...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1q9o. | + | [[Image:1q9o.jpg|left|200px]]<br /><applet load="1q9o" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1q9o" size=" | + | |
caption="1q9o, resolution 1.79Å" /> | caption="1q9o, resolution 1.79Å" /> | ||
'''S45-18 Fab Unliganded'''<br /> | '''S45-18 Fab Unliganded'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1Q9O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1Q9O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9O OCA]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 28: | ||
[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:43:18 2008'' |
Revision as of 14:43, 15 February 2008
|
S45-18 Fab Unliganded
Overview
High-resolution structures reveal how a germline antibody can recognize a, range of clinically relevant carbohydrate epitopes. The germline response, to a carbohydrate immunogen can be critical to survivability, with, selection for antibody gene segments that both confer protection against, common pathogens and retain the flexibility to adapt to new disease, organisms. We show here that antibody S25-2 binds several distinct, inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an, inherited monosaccharide residue binding site with a subset of, complementarity-determining regions (CDRs) of limited flexibility, positioned to recognize the remainder of an array of different epitopes., This strategy allows germline antibodies to adapt to different epitopes, while minimizing entropic penalties associated with the immobilization of, labile CDRs upon binding of antigen, and provides insight into the link, between the genetic origin of individual CDRs and their respective roles, in antigen recognition.
About this Structure
1Q9O is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588
Page seeded by OCA on Fri Feb 15 16:43:18 2008
Categories: Mus musculus | Protein complex | Brade, H. | Brade, L. | Evans, S.V. | Kosma, P. | MacKenzie, C.R. | Nguyen, H.P. | Seto, N.O. | MG | Anti-carbohydrate | Anti-lps | Antibody | Antigen-binding fragment | Fab | Immunoglobulin
