1qbh
From Proteopedia
(New page: 200px<br /> <applet load="1qbh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qbh" /> '''SOLUTION STRUCTURE OF A BACULOVIRAL INHIBIT...) |
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'''SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT'''<br /> | '''SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1QBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc binding domain]] | [[Category: zinc binding domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:43:46 2008'' |
Revision as of 14:43, 15 February 2008
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SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT
Overview
Members of the inhibitor of apoptosis (IAP) family of proteins are able to, inhibit cell death following viral infection, during development or in, cell lines in vitro. All IAP proteins bear one or more baculoviral IAP, repeats (BIRs). Here we describe the solution structure of the third BIR, domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has, a novel fold that is stabilized by zinc tetrahedrally coordinated by one, histidine and three cysteine residues. The structure consists of a series, of short alpha-helices and turns with the zinc packed in an unusually, hydrophobic environment created by residues that are highly conserved, among all BIRs.
About this Structure
1QBH is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat., Hinds MG, Norton RS, Vaux DL, Day CL, Nat Struct Biol. 1999 Jul;6(7):648-51. PMID:10404221
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