1qbj
From Proteopedia
(New page: 200px<br /> <applet load="1qbj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qbj, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1qbj. | + | [[Image:1qbj.jpg|left|200px]]<br /><applet load="1qbj" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1qbj, resolution 2.1Å" /> | caption="1qbj, resolution 2.1Å" /> | ||
'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1QBJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein/z-dna complex]] | [[Category: protein/z-dna complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:43:49 2008'' |
Revision as of 14:43, 15 February 2008
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CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX
Contents |
Overview
The editing enzyme double-stranded RNA adenosine deaminase includes a DNA, binding domain, Zalpha, which is specific for left-handed Z-DNA. The 2.1, angstrom crystal structure of Zalpha complexed to DNA reveals that the, substrate is in the left-handed Z conformation. The contacts between, Zalpha and Z-DNA are made primarily with the "zigzag" sugar-phosphate, backbone, which provides a basis for the specificity for the Z, conformation. A single base contact is observed to guanine in the syn, conformation, characteristic of Z-DNA. Intriguingly, the helix-turn-helix, motif, frequently used to recognize B-DNA, is used by Zalpha to contact, Z-DNA.
Disease
Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]
About this Structure
1QBJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:10364558
Page seeded by OCA on Fri Feb 15 16:43:49 2008
