1qf8
From Proteopedia
(New page: 200px<br /> <applet load="1qf8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qf8, resolution 1.74Å" /> '''TRUNCATED FORM OF C...) |
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caption="1qf8, resolution 1.74Å" /> | caption="1qf8, resolution 1.74Å" /> | ||
'''TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS'''<br /> | '''TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QF8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 1QF8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zn finger]] | [[Category: zn finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:44:13 2008'' |
Revision as of 14:44, 15 February 2008
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TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS
Overview
Protein kinase CK2 is a tetramer composed of two alpha catalytic subunits, and two beta regulatory subunits. The structure of a C-terminal truncated, form of the human beta subunit has been determined by X-ray, crystallography to 1.7 A resolution. One dimer is observed in the, asymmetric unit of the crystal. The most striking feature of the structure, is the presence of a zinc finger mediating the dimerization. The monomer, structure consists of two domains, one entirely alpha-helical and one, including the zinc finger. The dimer has a crescent shape holding a highly, acidic region at both ends. We propose that this acidic region is involved, in the interactions with the polyamines and/or catalytic subunits., Interestingly, conserved amino acid residues among beta subunit sequences, are clustered along one linear ridge that wraps around the entire dimer., This feature suggests that protein partners may interact with the dimer, through a stretch of residues in an extended conformation.
About this Structure
1QF8 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization., Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O, EMBO J. 1999 Jun 1;18(11):2930-40. PMID:10357806
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