1qgp
From Proteopedia
(New page: 200px<br /> <applet load="1qgp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qgp" /> '''NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR...) |
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'''NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES'''<br /> | '''NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QGP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1QGP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: z-dna recognition]] | [[Category: z-dna recognition]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:44:33 2008'' |
Revision as of 14:44, 15 February 2008
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NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES
Contents |
Overview
Double-stranded RNA deaminase I (ADAR1) contains the Z-DNA binding domain, Zalpha. Here we report the solution structure of free Zalpha and map the, interaction surface with Z-DNA, confirming roles previously assigned to, residues by mutagenesis. Comparison with the crystal structure of the, (Zalpha)(2)/Z-DNA complex shows that most Z-DNA contacting residues in, free Zalpha are prepositioned to bind Z-DNA, thus minimizing the entropic, cost of binding. Comparison with homologous, (alpha+beta)helix-turn-helix/B-DNA complexes suggests that binding of, Zalpha to B-DNA is disfavored by steric hindrance, but does not eliminate, the possibility that related domains may bind to both B- and Z-DNA.
Disease
Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]
About this Structure
1QGP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA., Schade M, Turner CJ, Kuhne R, Schmieder P, Lowenhaupt K, Herbert A, Rich A, Oschkinat H, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12465-70. PMID:10535945
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