1qnd
From Proteopedia
(New page: 200px<br /> <applet load="1qnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qnd" /> '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURE...) |
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'''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES'''<br /> | '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1QND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QND OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sterol carrier protein 2]] | [[Category: sterol carrier protein 2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:45:21 2008'' |
Revision as of 14:45, 15 February 2008
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STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES
Overview
The determination of the NMR structure of the sterol carrier protein-2, (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR, studies of nitroxide spin-labeled substrate binding are presented as a new, basis for investigations of the mode of action of SCP2. The SCP2 fold is, formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid, binding to a hydrophobic surface area formed by amino acid residues of the, first and third helices, and the beta-sheet, which are all located in the, polypeptide segment 8-102, was identified with the use of the spin-labeled, substrate 16-doxylstearic acid. In the free protein, the lipid-binding, site is covered by the C-terminal segment 105-123, suggesting that this, polypeptide segment, which carries the peroxisomal targeting signal, (PTS1), might be involved in the regulation of ligand binding.
About this Structure
1QND is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549
Page seeded by OCA on Fri Feb 15 16:45:21 2008
