1ax8
From Proteopedia
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{{STRUCTURE_1ax8| PDB=1ax8 | SCENE= }} | {{STRUCTURE_1ax8| PDB=1ax8 | SCENE= }} | ||
| - | === | + | ===Human obesity protein, leptin=== |
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==About this Structure== | ==About this Structure== | ||
| - | [[1ax8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AX8 OCA]. | + | [[1ax8]] is a 1 chain structure of [[Flock house virus B2 protein Suppression of RNA Silencing]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The May 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Leptin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_5 10.2210/rcsb_pdb/mom_2012_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AX8 OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Flock house virus B2 protein Suppression of RNA Silencing]] | + | *[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]] |
| - | *[[User:Mary Ball/Leptin]] | + | *[[Leptin (Hebrew)|Leptin (Hebrew)]] |
| - | *[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | + | *[[User:Mary Ball/Leptin|User:Mary Ball/Leptin]] |
| + | *[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:009144295</ref><ref group="xtra">PMID:011742118</ref><ref group="xtra">PMID:012215425</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Leptin]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Beals, J M.]] | [[Category: Beals, J M.]] | ||
[[Category: Briggs, S L.]] | [[Category: Briggs, S L.]] | ||
Revision as of 08:22, 9 May 2012
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| 1ax8, resolution 2.40Å () | |||||||||
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| Gene: | OBESE GENE (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Human obesity protein, leptin
Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of leptin: rather, serum leptin concentrations are increased and there is an apparent inability to transport it to the central nervous system (CNS). Injection of leptin into the CNS of overfed rodents resistant to peripheral administration was found to induce biological activity. Consequently, for the leptin to act as a weight-lowering hormone in human obesity, it appears that appropriate concentrations must be present in the CNS. This places a premium on understanding the structure of the hormone in order to design more potent and selective agonists. Here we report the crystal structure at 2.4A resolution of a human mutant OB protein (leptin-E100) that has comparable biological activity to wild type but which crystallizes more readily. The structure reveals a four-helix bundle similar to that of the long-chain helical cytokine family.
Crystal structure of the obese protein leptin-E100., Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW, Nature. 1997 May 8;387(6629):206-9. PMID:9144295
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1ax8 is a 1 chain structure of Flock house virus B2 protein Suppression of RNA Silencing with sequence from Homo sapiens. The May 2012 RCSB PDB Molecule of the Month feature on Leptin by David Goodsell is 10.2210/rcsb_pdb/mom_2012_5. Full crystallographic information is available from OCA.
See Also
- Flock house virus B2 protein Suppression of RNA Silencing
- Leptin (Hebrew)
- User:Mary Ball/Leptin
- User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing
Reference
- Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387(6629):206-9. PMID:9144295 doi:10.1038/387206a0
- Shortle D. Composites of local structure propensities: evidence for local encoding of long-range structure. Protein Sci. 2002 Jan;11(1):18-26. PMID:11742118
- Hill EE, Morea V, Chothia C. Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. J Mol Biol. 2002 Sep 6;322(1):205-33. PMID:12215425
