1rtb
From Proteopedia
(New page: 200px<br /> <applet load="1rtb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rtb, resolution 2.5Å" /> '''CRYSTAL STRUCTURE DI...) |
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caption="1rtb, resolution 2.5Å" /> | caption="1rtb, resolution 2.5Å" /> | ||
'''CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A'''<br /> | '''CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RTB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http:// | + | 1RTB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rna)]] | [[Category: rna)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:49:48 2008'' |
Revision as of 14:49, 15 February 2008
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CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A
Overview
The crystal structure of ribonuclease A with bound thymidylic acid, tetramer is reported at 2.5-A resolution. The diffusion of the tetramer, into native orthorhombic crystals of the ribonuclease allows for the, formation of a structurally stable complex where the single-stranded, nucleic acid enters and leaves the enzyme's catalytic region in a, persistent 5'-3' direction. The binding of the tetramer to the enzyme's, surface is facilitated and mediated by electrostatic interactions between, basic protein residues and nucleotide phosphates. Two pyrimidine, nucleotides are bound to the enzyme's active site in a manner similar to, that observed for other complexes between ribonuclease A and nucleic acid, oligomers.
About this Structure
1RTB is a Single protein structure of sequence from Bos taurus. Active as Pancreatic ribonuclease, with EC number 3.1.27.5 Full crystallographic information is available from OCA.
Reference
Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A., Birdsall DL, McPherson A, J Biol Chem. 1992 Nov 5;267(31):22230-6. PMID:1429575
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