1rtg
From Proteopedia
(New page: 200px<br /> <applet load="1rtg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rtg, resolution 2.6Å" /> '''C-TERMINAL DOMAIN (H...) |
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caption="1rtg, resolution 2.6Å" /> | caption="1rtg, resolution 2.6Å" /> | ||
'''C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2'''<br /> | '''C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RTG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http:// | + | 1RTG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: metzincins]] | [[Category: metzincins]] | ||
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Revision as of 14:49, 15 February 2008
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C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2
Contents |
Overview
In common with most other matrix metalloproteinases, gelatinase A has a, non-catalytic C-terminal domain that displays sequence homology to, haemopexin. Crystals of this domain were used by molecular replacement to, solve its molecular structure at 2.6 A resolution, which was refined to an, R value of 17.9%. This structure has a disc-like shape, with the chain, folded into a beta-propeller structure that has pseudo four-fold symmetry., Although the topology and the side-chain arrangement are very similar to, the equivalent domain of fibroblast collagenase, significant differences, in surface charge and contouring are observable on 1 side of the, gelatinase A disc. This difference might be a factor in allowing the, gelatinase A C-terminal domain to bind to natural inhibitor TIMP-2.
Disease
Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]
About this Structure
1RTG is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Gelatinase A, with EC number 3.4.24.24 Full crystallographic information is available from OCA.
Reference
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function., Gohlke U, Gomis-Ruth FX, Crabbe T, Murphy G, Docherty AJ, Bode W, FEBS Lett. 1996 Jan 8;378(2):126-30. PMID:8549817
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