1rvf
From Proteopedia
(New page: 200px<br /> <applet load="1rvf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rvf, resolution 4.0Å" /> '''FAB COMPLEXED WITH I...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1rvf. | + | [[Image:1rvf.jpg|left|200px]]<br /><applet load="1rvf" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1rvf" size=" | + | |
caption="1rvf, resolution 4.0Å" /> | caption="1rvf, resolution 4.0Å" /> | ||
'''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS'''<br /> | '''FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1RVF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http:// | + | 1RVF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_10 Human rhinovirus 10], [http://en.wikipedia.org/wiki/Human_rhinovirus_sp. Human rhinovirus sp.] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1RVF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb20_1.html Poliovirus and Rhinovirus]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVF OCA]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 27: | ||
[[Category: thiol protease]] | [[Category: thiol protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:50:32 2008'' |
Revision as of 14:50, 15 February 2008
|
FAB COMPLEXED WITH INTACT HUMAN RHINOVIRUS
Overview
The three-dimensional structure of intact human rhinovirus 14 (HRV-14), complexed with Fab fragments (Fab17-IA) from a strongly neutralizing, antibody that binds bivalently to the virion has been determined to 4.0, angstrom resolution by a combination of X-ray crystallography and, cryo-electron microscopy. In contradiction to the most commonly held model, of antibody-mediated neutralization, Fab17-IA does not induce a, conformational change in the HRV-14 capsid. Instead, the paratope of the, antibody undergoes a large conformational change to accommodate the, epitope. Unlike any previously described antibody-antigen structure, the, conserved framework region of the antibody makes extensive contact with, the viral surface. Fab17-IA penetrates deep within the canyon in which the, cellular receptor for HRV-14 binds. Hence, it is unlikely that viral, quaternary structure evolves merely to evade immune recognition. Instead, the shape and position of the receptor-binding region on a virus probably, dictates receptor binding and subsequent uncoating events and has little, or no influence on concealing the virus from the immune system.
About this Structure
1RVF is a Protein complex structure of sequences from Human rhinovirus 10, Human rhinovirus sp. and Mus musculus. The following page contains interesting information on the relation of 1RVF with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.
Reference
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon., Smith TJ, Chase ES, Schmidt TJ, Olson NH, Baker TS, Nature. 1996 Sep 26;383(6598):350-4. PMID:8848050
Page seeded by OCA on Fri Feb 15 16:50:32 2008
Categories: Human rhinovirus 10 | Human rhinovirus sp. | Mus musculus | Poliovirus and Rhinovirus | Protein complex | Smith, T.J. | Coat protein | Complex (coat protein/immunoglobulin) | Core protein | Hydrolase | Icosahedral virus | Myristylation | Polyprotein | Rna-directed rna polymerase | Thiol protease
