1rwq
From Proteopedia
(New page: 200px<br /> <applet load="1rwq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rwq, resolution 2.20Å" /> '''Human Dipeptidyl pe...) |
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| - | [[Image:1rwq. | + | [[Image:1rwq.jpg|left|200px]]<br /><applet load="1rwq" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1rwq" size=" | + | |
caption="1rwq, resolution 2.20Å" /> | caption="1rwq, resolution 2.20Å" /> | ||
'''Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine'''<br /> | '''Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RWQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and 5AP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | + | 1RWQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=5AP:'>5AP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: exopeptidase]] | [[Category: exopeptidase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:50:39 2008'' |
Revision as of 14:50, 15 February 2008
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Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine
Overview
The influence of aromatic substitution on a newly discovered class of, inhibitors of dipeptidyl peptidase IV was investigated. A 10(5)-fold, increase in potency was achieved by the optimization of aromatic, substituents in a parallel chemistry program. The observed SAR could be, explained by an X-ray structure of the protein-ligand complex.
About this Structure
1RWQ is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
Reference
Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents., Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Boehringer M, Hennig M, Kuhn B, Loeffler BM, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1491-3. PMID:15006388
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