1s5q
From Proteopedia
(New page: 200px<br /> <applet load="1s5q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s5q" /> '''Solution Structure of Mad1 SID-mSin3A PAH2 ...) |
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'''Solution Structure of Mad1 SID-mSin3A PAH2 Complex'''<br /> | '''Solution Structure of Mad1 SID-mSin3A PAH2 Complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S5Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1S5Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5Q OCA]. |
==Reference== | ==Reference== | ||
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[[Category: repressor-corepressor complex]] | [[Category: repressor-corepressor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:52:18 2008'' |
Revision as of 14:52, 15 February 2008
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Solution Structure of Mad1 SID-mSin3A PAH2 Complex
Contents |
Overview
Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor, is an obligatory step in many eukaryotic gene silencing pathways. Here we, show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner by targeting the, mammalian Sin3A (mSin3A) PAH2 domain. HBP1 is unrelated to the Mad1, repressor for which high-resolution structures in complex with PAH2 have, been described. We show that like Mad1, the HBP1 transrepression domain, binds through a helical structure to the hydrophobic cleft of mSin3A PAH2., Notably, the HBP1 helix binds PAH2 in a reversed orientation relative to, Mad1 and, equally unexpectedly, this is correlated with a chain reversal, of the minimal Sin3 interaction motifs. These results not only provide, insights into how multiple, unrelated transcription factors recruit the, same coregulator, but also have implications for how sequence similarity, searches are conducted.
Disease
Known diseases associated with this structure: Lymphoma, somatic OMIM:[602686], Prostate cancer, somatic OMIM:[602686]
About this Structure
1S5Q is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations., Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, Nat Struct Mol Biol. 2004 Aug;11(8):738-46. Epub 2004 Jul 4. PMID:15235594
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