1st0
From Proteopedia
(New page: 200px<br /> <applet load="1st0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1st0, resolution 1.9Å" /> '''Structure of DcpS bo...) |
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| - | [[Image:1st0. | + | [[Image:1st0.jpg|left|200px]]<br /><applet load="1st0" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1st0, resolution 1.9Å" /> | caption="1st0, resolution 1.9Å" /> | ||
'''Structure of DcpS bound to m7GpppG'''<br /> | '''Structure of DcpS bound to m7GpppG'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ST0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with YT3 and GTG as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1ST0 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http:// | + | 1ST0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=YT3:'>YT3</scene> and <scene name='pdbligand=GTG:'>GTG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1ST0 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ST0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rna decay]] | [[Category: rna decay]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:54:40 2008'' |
Revision as of 14:54, 15 February 2008
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Structure of DcpS bound to m7GpppG
Overview
Complete removal of residual N-7 guanine cap from degraded messenger RNA, is necessary to prevent accumulation of intermediates that might interfere, with RNA processing, export, and translation. The human scavenger, decapping enzyme, DcpS, catalyzes residual cap hydrolysis following mRNA, degradation, releasing N-7 methyl guanosine monophosphate and, 5'-diphosphate terminated cap or mRNA products. DcpS structures bound to, m(7)GpppG or m(7)GpppA reveal an asymmetric DcpS dimer that simultaneously, creates an open nonproductive DcpS-cap complex and a closed productive, DcpS-cap complex that alternate via 30 A domain movements. Structural and, biochemical analysis suggests an autoregulatory mechanism whereby, premature decapping mRNA is prevented by blocking the conformational, changes that are required to form a closed productive active site capable, of cap hydrolysis.
About this Structure
1ST0 is a Single protein structure of sequence from Homo sapiens with and as ligands. The following page contains interesting information on the relation of 1ST0 with [Exosomes]. Full crystallographic information is available from OCA.
Reference
Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:15068804
Page seeded by OCA on Fri Feb 15 16:54:40 2008
Categories: Exosomes | Homo sapiens | Single protein | Fabrega, C. | Gu, M. | Kiledjian, M. | Lima, C.D. | Liu, H. | Liu, S.W. | GTG | YT3 | Cap | Decapping | Exosome | Hit protein | Messenger rna | Mrna | Rna decay
