1tcr
From Proteopedia
(New page: 200px<br /> <applet load="1tcr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tcr, resolution 2.5Å" /> '''MURINE T-CELL ANTIGE...) |
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| - | [[Image:1tcr. | + | [[Image:1tcr.jpg|left|200px]]<br /><applet load="1tcr" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1tcr, resolution 2.5Å" /> | caption="1tcr, resolution 2.5Å" /> | ||
'''MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE'''<br /> | '''MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TCR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1TCR with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http:// | + | 1TCR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1TCR with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb62_1.html Major Histocompatibility Complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:56:16 2008'' |
Revision as of 14:56, 15 February 2008
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MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE
Overview
The central event in the cellular immune response to invading, microorganisms is the specific recognition of foreign peptides bound to, major histocompatibility complex (MHC) molecules by the alphabeta T cell, receptor (TCR). The x-ray structure of the complete extracellular fragment, of a glycosylated alphabeta TCR was determined at 2.5 angstroms, and its, orientation bound to a class I MHC-peptide (pMHC) complex was elucidated, from crystals of the TCR-pMHC complex. The TCR resembles an antibody in, the variable Valpha and Vbeta domains but deviates in the constant Calpha, domain and in the interdomain pairing of Calpha with Cbeta. Four of seven, possible asparagine-linked glycosylation sites have ordered carbohydrate, moieties, one of which lies in the Calpha-Cbeta interface. The TCR, combining site is relatively flat except for a deep hydrophobic cavity, between the hypervariable CDR3s (complementarity-determining regions) of, the alpha and beta chains. The 2C TCR covers the class I MHC H-2Kb binding, groove so that the Valpha CDRs 1 and 2 are positioned over the, amino-terminal region of the bound dEV8 peptide, the Vbeta chain CDRs 1, and 2 are over the carboxyl-terminal region of the peptide, and the Valpha, and Vbeta CDR3s straddle the peptide between the helices around the, central position of the peptide.
About this Structure
1TCR is a Protein complex structure of sequences from Mus musculus with and as ligands. The following page contains interesting information on the relation of 1TCR with [Major Histocompatibility Complex]. Full crystallographic information is available from OCA.
Reference
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex., Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA, Science. 1996 Oct 11;274(5285):209-19. PMID:8824178
Page seeded by OCA on Fri Feb 15 16:56:16 2008
