4ajw

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'''Unreleased structure'''
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[[Image:4ajw.jpg|left|200px]]
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The entry 4ajw is ON HOLD until Paper Publication
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{{STRUCTURE_4ajw| PDB=4ajw | SCENE= }}
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Authors: Certal, V., Halley, F., Virone-Oddos, A., Delorme, C., Karlsson, A., Rak, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Carry, J.C., Abecassis, P.Y., Lejeune, P., Bonnevaux, H., Nicolas, J.P., Bertrand, T., Marquette, J.P., Michot, N., Benard, T., Below, P., Vade, I., Chatreaux, F., Lebourg, G., Pilorge, F., Angouillant-Boniface, O., Louboutin, A., Lengauer, C., Schio, L.
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===Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers"===
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Description: Discovery and Optimization of New Benzimidazole-and Benzoxazole-Pyrimidone Selective PI3Kb Inhibitors for the Treatment of PTEN-Deficient Cancers
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{{ABSTRACT_PUBMED_22524426}}
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==About this Structure==
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[[4ajw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJW OCA].
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==Reference==
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<ref group="xtra">PMID:022524426</ref><references group="xtra"/>
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[[Category: Mus musculus]]
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[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
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[[Category: Abecassis, P Y.]]
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[[Category: Angouillant-Boniface, O.]]
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[[Category: Below, P.]]
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[[Category: Benard, T.]]
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[[Category: Bertrand, T.]]
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[[Category: Bonnevaux, H.]]
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[[Category: Carry, J C.]]
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[[Category: Certal, V.]]
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[[Category: Chatreaux, F.]]
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[[Category: Delorme, C.]]
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[[Category: El-Ahmad, Y.]]
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[[Category: Filoche-Romme, B.]]
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[[Category: Halley, F.]]
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[[Category: Karlsson, A.]]
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[[Category: Lebourg, G.]]
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[[Category: Lejeune, P.]]
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[[Category: Lengauer, C.]]
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[[Category: Louboutin, A.]]
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[[Category: Marquette, J P.]]
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[[Category: Michot, N.]]
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[[Category: Nicolas, J P.]]
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[[Category: Pilorge, F.]]
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[[Category: Rak, A.]]
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[[Category: Schio, L.]]
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[[Category: Thompson, F.]]
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[[Category: Vade, I.]]
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[[Category: Virone-Oddos, A.]]
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[[Category: P110d]]
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[[Category: Transferase]]

Revision as of 09:13, 16 May 2012

Template:STRUCTURE 4ajw

Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers"

Template:ABSTRACT PUBMED 22524426

About this Structure

4ajw is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Romme B, El-Ahmad Y, Carry JC, Abecassis PY, Lejeune P, Vincent L, Bonnevaux H, Nicolas JP, Bertrand T, Marquette JP, Michot N, Benard T, Below P, Vade I, Chatreaux F, Lebourg G, Pilorge F, Angouillant-Boniface O, Louboutin A, Lengauer C, Schio L. Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers. J Med Chem. 2012 May 2. PMID:22524426 doi:10.1021/jm300241b

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