Nuclear receptor coactivator
From Proteopedia
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Revision as of 10:46, 17 May 2012
Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA are involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA3 shows histone acetyltransferase activity.
3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein
2c52 – hNCOA1 residues 920-970 + CREB-binding protein
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
