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4e4x

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Revision as of 04:57, 23 May 2012

Image:4e4x.png

Template:STRUCTURE 4e4x

Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor

Template:ABSTRACT PUBMED 22534450

About this Structure

4e4x is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ren L, Ahrendt KA, Grina J, Laird ER, Buckmelter AJ, Hansen JD, Newhouse B, Moreno D, Wenglowsky S, Dinkel V, Gloor SL, Hastings G, Rana S, Rasor K, Risom T, Sturgis HL, Voegtli WC, Mathieu S. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Bioorg Med Chem Lett. 2012 May 15;22(10):3387-91. Epub 2012 Apr 10. PMID:22534450 doi:10.1016/j.bmcl.2012.04.015

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OCA

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