4e4x
From Proteopedia
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Revision as of 04:57, 23 May 2012
Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor
Template:ABSTRACT PUBMED 22534450
About this Structure
4e4x is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ren L, Ahrendt KA, Grina J, Laird ER, Buckmelter AJ, Hansen JD, Newhouse B, Moreno D, Wenglowsky S, Dinkel V, Gloor SL, Hastings G, Rana S, Rasor K, Risom T, Sturgis HL, Voegtli WC, Mathieu S. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Bioorg Med Chem Lett. 2012 May 15;22(10):3387-91. Epub 2012 Apr 10. PMID:22534450 doi:10.1016/j.bmcl.2012.04.015
