4ejn
From Proteopedia
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| + | {{STRUCTURE_4ejn| PDB=4ejn | SCENE= }} | ||
| - | + | ===Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide=== | |
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| + | The line below this paragraph, {{ABSTRACT_PUBMED_22533986}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 22533986 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_22533986}} | ||
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| + | ==About this Structure== | ||
| + | [[4ejn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJN OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022533986</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Eathiraj, S.]] | ||
| + | [[Category: Akt1]] | ||
| + | [[Category: Allosteric inhibitor]] | ||
| + | [[Category: Atpase]] | ||
| + | [[Category: Autoinhibition]] | ||
| + | [[Category: Hydrophobic collapase]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Kinase inhibitor]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 06:01, 23 May 2012
Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide
Template:ABSTRACT PUBMED 22533986
About this Structure
4ejn is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ashwell MA, Lapierre JM, Brassard C, Bresciano K, Bull C, Cornell-Kennon S, Eathiraj S, France D, Hall T, Hill J, Kelleher E, Khanapurkar S, Kizer D, Koerner S, Link J, Liu Y, Makhija S, Moussa M, Namdev N, Nicewonger R, Nguyen K, Palma R, Szwaya J, Tandon M, Uppalapati U, Vensel D, Volak LP, Volckova E, Westlund N, Wu H, Yang RY, Chan TC. Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl) pyridin-2-amines: Orally Bioavailable, Selective and Potent ATP-independent Akt Inhibitors. J Med Chem. 2012 Apr 25. PMID:22533986 doi:10.1021/jm300276x
