Sandbox Reserved 554

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(New page: <!-- PLEASE DO NOT DELETE THIS TEMPLATE --> {{NCSU_BIOL414_Sandbox}} <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> Hi everyone, Here is your very own Proteopedia Page to play with. This page...)
Current revision (17:25, 24 May 2012) (edit) (undo)
 
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{{NCSU_BIOL414_Sandbox}}
{{NCSU_BIOL414_Sandbox}}
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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Hi everyone,
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Hi Lisa,
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Here is your very own Proteopedia Page to play with.
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This page is not publicly available yet,
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Here is your very own Protopedia page for pdb code: 3MJG.
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so don't worry about making mistakes that
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Your presentation date is scheduled for: June 20.
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other people will see.
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Have Fun!
Have Fun!
Greg Buhrman
Greg Buhrman
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[[Image:3mjg.png|left|200px]]
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<!--
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The line below this paragraph, containing "STRUCTURE_3mjg", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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{{STRUCTURE_3mjg| PDB=3mjg | SCENE= }}
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===The structure of a platelet derived growth factor receptor complex===
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<!--
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The line below this paragraph, {{ABSTRACT_PUBMED_20534510}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 20534510 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20534510}}
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==About this Structure==
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3MJG is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJG OCA].
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==Reference==
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<ref group="xtra">PMID:20534510</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: He, X.]]
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[[Category: Shim, A H.R.]]
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[[Category: Growth factor-receptor complex]]
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[[Category: Hormone-transferase complex]]
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[[Category: Protein-protein complex]]
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[[Category: Transferase-hormone complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:07:32 2010''

Current revision

This Sandbox is Reserved from 05/22/2012, through 07/22/2012 for use in the course "BIOL 414" taught by Greg Buhrman at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 551 through Sandbox Reserved 590.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Hi Lisa,

Here is your very own Protopedia page for pdb code: 3MJG. Your presentation date is scheduled for: June 20.

Have Fun!

Greg Buhrman


PDB ID 3mjg

Drag the structure with the mouse to rotate
3mjg, resolution 2.30Å ()
Ligands: ,
Gene: PDGF2, PDGFB, SIS (Homo sapiens), PDGFRB (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



The structure of a platelet derived growth factor receptor complex

Publication Abstract from PubMed

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after processing. The structure of the PDGF-A/propeptide complex reveals this conserved, hydrophobic association mode. We also present the structure of the complex between PDGF-B and the first three Ig domains of PDGFRbeta, showing that two PDGF-B protomers clamp PDGFRbeta at their dimerization seam. The PDGF-B:PDGFRbeta interface is predominantly hydrophobic, and PDGFRs and the PDGF propeptides occupy overlapping positions on mature PDGFs, rationalizing the need of propeptides by PDGFs to cover functionally important hydrophobic surfaces during secretion. A large-scale structural organization and rearrangement is observed for PDGF-B upon receptor binding, in which the PDGF-B L1 loop, disordered in the structure of the free form, adopts a highly specific conformation to form hydrophobic interactions with the third Ig domain of PDGFRbeta. Calorimetric data also shows that the membrane-proximal homotypic PDGFRalpha interaction, albeit required for activation, contributes negatively to ligand binding. The structural and biochemical data together offer insights into PDGF-PDGFR signaling, as well as strategies for PDGF-antagonism.

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex., Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X, Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11307-12. Epub 2010 Jun 2. PMID:20534510

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3MJG is a 4 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X. Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11307-12. Epub 2010 Jun 2. PMID:20534510

Page seeded by OCA on Wed Aug 18 11:07:32 2010

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