This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1xh3
From Proteopedia
(New page: 200px<br /> <applet load="1xh3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xh3, resolution 1.48Å" /> '''Conformational Rest...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1xh3. | + | [[Image:1xh3.jpg|left|200px]]<br /><applet load="1xh3" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1xh3" size=" | + | |
caption="1xh3, resolution 1.48Å" /> | caption="1xh3, resolution 1.48Å" /> | ||
'''Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501'''<br /> | '''Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1XH3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1XH3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XH3 OCA]. |
==Reference== | ==Reference== | ||
| Line 27: | Line 26: | ||
[[Category: immune system]] | [[Category: immune system]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:09:17 2008'' |
Revision as of 15:09, 15 February 2008
|
Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501
Contents |
Overview
Human HLA-B*3501 binds an antigenic peptide of 14-aa length derived from, an alternative reading frame of M-CSF with high affinity. Due to its, extraordinary length, the exact HLA binding mode was unpredictable. The, crystal structure of HLA-B*3501 at 1.5 A shows that the N and C termini of, the peptide are embedded in the A and F pockets, respectively, similar to, a peptide of normal length. The central part of the 14-meric peptide, bulges flexibly out of the groove. Two variants of the alternative reading, frame of M-CSF peptide substituted at P2 or P2 and P9 with Ala display, weak or no T cell activation. Their structure differs mainly in, flexibility and conformation from the agonistic peptide. Moreover, the, variants induce subtle changes of MHC alpha-helical regions implicated as, critical for TCR contact. The TCR specifically recognizing this, peptide/MHC complex exhibits CDR3 length within the normal range, suggesting major conformational adaptations of this receptor upon, peptide/MHC binding. Thus, the potential antigenic repertoire recognizable, by CTLs is larger than currently thought.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142830], Hypoproteinemia, hypercatabolic OMIM:[109700], Spondyloarthropathy, susceptibility to, 1 OMIM:[142830], Stevens-Johnson syndrome, carbamazepine-induced, susceptibility to OMIM:[142830]
About this Structure
1XH3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501., Probst-Kepper M, Hecht HJ, Herrmann H, Janke V, Ocklenburg F, Klempnauer J, van den Eynde BJ, Weiss S, J Immunol. 2004 Nov 1;173(9):5610-6. PMID:15494511
Page seeded by OCA on Fri Feb 15 17:09:17 2008
