3u9c

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'''Unreleased structure'''
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[[Image:3u9c.jpg|left|200px]]
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The entry 3u9c is ON HOLD until Paper Publication
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{{STRUCTURE_3u9c| PDB=3u9c | SCENE= }}
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Authors: Klopffleisch, K., Issinger, O.-G., Niefind, K.
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===Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin===
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Description: Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin
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{{ABSTRACT_PUBMED_19796713}}
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==About this Structure==
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[[3u9c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9C OCA].
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==Reference==
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<ref group="xtra">PMID:019796713</ref><ref group="xtra">PMID:018291315</ref><ref group="xtra">PMID:019387553</ref><ref group="xtra">PMID:015740749</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Issinger, O G.]]
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[[Category: Klopffleisch, K.]]
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[[Category: Niefind, K.]]
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[[Category: Atp ck2beta]]
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[[Category: Atp:protein phosphotransferase]]
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[[Category: Eukaryotic protein kinase fold]]
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[[Category: Protein kinase]]
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[[Category: Protein kinase ck2 casein kinase 2]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:00, 30 May 2012

Image:3u9c.jpg

Template:STRUCTURE 3u9c

Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin

Template:ABSTRACT PUBMED 19796713

About this Structure

3u9c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Niefind K, Issinger OG. Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design. Biochim Biophys Acta. 2010 Mar;1804(3):484-92. Epub 2009 Sep 28. PMID:19796713 doi:10.1016/j.bbapap.2009.09.022
  • Raaf J, Brunstein E, Issinger OG, Niefind K. The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chem Biol. 2008 Feb;15(2):111-7. PMID:18291315 doi:http://dx.doi.org/10.1016/j.chembiol.2007.12.012
  • Niefind K, Raaf J, Issinger OG. Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. Cell Mol Life Sci. 2009 Jun;66(11-12):1800-16. PMID:19387553 doi:10.1007/s00018-009-9149-8
  • Yde CW, Ermakova I, Issinger OG, Niefind K. Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J Mol Biol. 2005 Mar 25;347(2):399-414. Epub 2005 Jan 18. PMID:15740749 doi:http://dx.doi.org/10.1016/j.jmb.2005.01.003

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