1xo5
From Proteopedia
(New page: 200px<br /> <applet load="1xo5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xo5, resolution 1.99Å" /> '''Crystal structure o...) |
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caption="1xo5, resolution 1.99Å" /> | caption="1xo5, resolution 1.99Å" /> | ||
'''Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein'''<br /> | '''Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1XO5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1XO5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XO5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: kinase interacting protein]] | [[Category: kinase interacting protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:09:49 2008'' |
Revision as of 15:09, 15 February 2008
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Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein
Contents |
Overview
CIB1 (CIB) is an EF-hand-containing protein that binds multiple effector, proteins, including the platelet alphaIIbbeta3 integrin and several, serine/threonine kinases and potentially modulates their function. The, crystal structure for Ca(2+)-bound CIB1 has been determined at 2.0 A, resolution and reveals a compact alpha-helical protein containing four, EF-hands, the last two of which bind calcium ions in the standard fashion, seen in many other EF-hand proteins. CIB1 shares high structural, similarity with calcineurin B and the neuronal calcium sensor (NCS) family, of EF-hand-containing proteins. Most importantly, like calcineurin B and, NCS proteins, which possess a large hydrophobic pocket necessary for, ligand binding, CIB1 contains a hydrophobic pocket that has been, implicated in ligand binding by previous mutational analysis. However, unlike several NCS proteins, Ca(2+)-bound CIB1 is largely monomeric, whether bound to a relevant peptide ligand or ligand-free. Differences in, structure, oligomeric state, and phylogeny define a new family of, CIB1-related proteins that extends from arthropods to humans.
Disease
Known disease associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]
About this Structure
1XO5 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins., Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV, J Biol Chem. 2005 Mar 4;280(9):8407-15. Epub 2004 Dec 1. PMID:15574431
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