Sandbox southuniversity6
From Proteopedia
(Difference between revisions)
(New page: ==Medicinal Chemistry of HIV Integrase Inhibitors==<StructureSection load='RLT' size='500' side='right' caption='Structure of the first HIV integrase inhibitor to market, raltegravir (PDB ...) |
|||
| Line 1: | Line 1: | ||
| - | ==Medicinal Chemistry of HIV Integrase Inhibitors==<StructureSection load='RLT' size='500' side='right' caption='Structure of the first HIV integrase inhibitor to market, raltegravir (PDB entry [[RLT]])' scene=''> | + | ==Medicinal Chemistry of HIV Integrase Inhibitors== |
| + | |||
| + | When AIDS was first discovered in the 1980s, an individual's prognosis was grim, with a life expectancy on the order of 10 years. With development of effective antiviral drugs, this has increased up to 50 years. The HIV virus encodes several enzymes that are drug targets. The first effective drugs that were developed inhibit [[reverse transcriptase]]. | ||
| + | |||
| + | |||
| + | |||
| + | <StructureSection load='RLT' size='500' side='right' caption='Structure of the first HIV integrase inhibitor to market, raltegravir (PDB entry [[RLT]])' scene=''>The structure to the left is the first HIV integrase that has made it's way to market, raltegravir (Isentress). | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:01, 1 June 2012
Medicinal Chemistry of HIV Integrase Inhibitors
When AIDS was first discovered in the 1980s, an individual's prognosis was grim, with a life expectancy on the order of 10 years. With development of effective antiviral drugs, this has increased up to 50 years. The HIV virus encodes several enzymes that are drug targets. The first effective drugs that were developed inhibit reverse transcriptase.
| |||||||||||
