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2vz0

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Revision as of 08:55, 2 June 2012

Image:2vz0.png

Template:STRUCTURE 2vz0

PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066641

Template:ABSTRACT PUBMED 19748480

About this Structure

2vz0 is a 4 chain structure with sequence from Trypanosoma brucei brucei. Full crystallographic information is available from OCA.

Reference

  • Shanks EJ, Ong HB, Robinson DA, Thompson S, Sienkiewicz N, Fairlamb AH, Frearson JA. Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase. Anal Biochem. 2010 Jan 15;396(2):194-203. Epub 2009 Sep 11. PMID:19748480 doi:10.1016/j.ab.2009.09.003
  • Dawson A, Gibellini F, Sienkiewicz N, Tulloch LB, Fyfe PK, McLuskey K, Fairlamb AH, Hunter WN. Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate. Mol Microbiol. 2006 Sep;61(6):1457-68. PMID:16968221 doi:10.1111/j.1365-2958.2006.05332.x

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