1ytb
From Proteopedia
(New page: 200px<br /> <applet load="1ytb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ytb, resolution 1.800Å" /> '''CRYSTAL STRUCTURE ...) |
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| - | [[Image:1ytb. | + | [[Image:1ytb.jpg|left|200px]]<br /><applet load="1ytb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ytb" size=" | + | |
caption="1ytb, resolution 1.800Å" /> | caption="1ytb, resolution 1.800Å" /> | ||
'''CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YTB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http:// | + | 1YTB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:12:33 2008'' |
Revision as of 15:12, 15 February 2008
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CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX
Overview
The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows, that the eight base pairs of the TATA box bind to the concave surface of, TBP by bending towards the major groove with unprecedented severity. This, produces a wide open, underwound, shallow minor groove which forms a, primarily hydrophobic interface with the entire under-surface of the TBP, saddle. The severe bend and a positive writhe radically alter the, trajectory of the flanking B-form DNA.
About this Structure
1YTB is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTB with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:8413604
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