1zml
From Proteopedia
(New page: 200px<br /> <applet load="1zml" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zml, resolution 2.25Å" /> '''Crystal Structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1zml. | + | [[Image:1zml.jpg|left|200px]]<br /><applet load="1zml" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1zml" size=" | + | |
caption="1zml, resolution 2.25Å" /> | caption="1zml, resolution 2.25Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine'''<br /> | '''Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1ZML is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, BCT and 412 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | + | 1ZML is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=BCT:'>BCT</scene> and <scene name='pdbligand=412:'>412</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZML OCA]. |
==Reference== | ==Reference== | ||
| Line 32: | Line 31: | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:13:22 2008'' |
Revision as of 15:13, 15 February 2008
|
Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine
Contents |
Overview
A series of functionalized aryl boronic acids were synthesized and, evaluated as potential inhibitors of factor XIa. Crystal structures of the, protein-inhibitor complexes led to the design and synthesis of second, generation compounds showing single digit micromolar inhibition against, FXIa and selectivity against thrombin, trypsin, and FXa.
Disease
Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]
About this Structure
1ZML is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Coagulation factor XIa, with EC number 3.4.21.27 Full crystallographic information is available from OCA.
Reference
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa., Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5022-7. Epub 2006 Jul 28. PMID:16876411
Page seeded by OCA on Fri Feb 15 17:13:22 2008
Categories: Coagulation factor XIa | Homo sapiens | Single protein | Babine, R.E. | Bibbins, F. | Gorga, J.C. | Jin, L. | Lazarova, T.I. | Meyers, H.V. | Rynkiewicz, M.J. | Strickler, J.E. | 412 | BCT | SO4 | Fxi | Inhibitor
