1upx

From Proteopedia

Revision as of 11:15, 30 October 2007

THE CRYSTAL STRUCTURE OF THE HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO DESULFURICANS CONTAINING MOLECULES IN THE OXIDIZED AND REDUCED STATES.

Overview

The hybrid cluster protein (HCP) from the sulfate-reducing bacteria, Desulfovibrio desulfuricans ATCC 27774 has been isolated and crystallized, anaerobically. The protein sample used in the crystallization studies was, several months old, having been stored at 193 K, and initial crystal, structure studies were unable to fully resolve details of the hybrid, cluster despite the use of high-resolution data to 1.25 A collected at the, ESRF, Grenoble, France. Full elucidation of the structure has only become, possible with the complete knowledge of the as-isolated and fully reduced, crystal structures. The analysis clarifies the significant movements in, the position of the Fe atom linked to the persulfide moiety in the, oxidized as-isolated protein and the S atom of the persulfide itself as, ... [(full description)]

About this Structure

1UPX is a [Single protein] structure of sequence from [Desulfovibrio desulfuricans] with SF4, SF3, FSO and MES as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of the hybrid cluster protein (HCP) from Desulfovibrio desulfuricans ATCC 27774 containing molecules in the oxidized and reduced states., Macedo S, Aragao D, Mitchell EP, Lindley P, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2065-71. Epub 2003, Nov 27. PMID:14646063

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