3gw9
From Proteopedia
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Revision as of 10:03, 2 June 2012
Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei bound to an inhibitor N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxaziazol-2-yl)benzamide
Template:ABSTRACT PUBMED 19923211
About this Structure
3gw9 is a 4 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.
Reference
- Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15;285(3):1773-80. Epub 2009 Nov 18. PMID:19923211 doi:M109.067470
Categories: Sterol 14-demethylase | Trypanosoma brucei | Hargrove, T Y. | Harp, J. | Lepesheva, G I. | Waterman, M R. | Wawrzak, Z. | Cyp51 | Cytochrome p450 | Endoplasmic reticulum | Heme | Heme-thiolate protein | Iron | Lipid | Monooxygenase | Oxidoreductase | Sterol 14alpha-demethylase | Sterol biosynthesis
