3hod

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Revision as of 15:34, 2 June 2012

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Template:STRUCTURE 3hod

Contents 1 Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid 2 About this Structure 3 See Also 4 Reference

Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid

Template:ABSTRACT PUBMED 19775169

About this Structure

3hod is a 2 chain structure of Peroxisome Proliferator-Activated Receptors with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Peroxisome Proliferator-Activated Receptors

Reference

• Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G, Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F. New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. J Med Chem. 2009 Oct 22;52(20):6382-93. PMID:19775169 doi:10.1021/jm900941b
• Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h