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2arw
From Proteopedia
(New page: 200px<br /> <applet load="2arw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2arw" /> '''The solution structure of the membrane prox...) |
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| - | [[Image:2arw.gif|left|200px]]<br /> | + | [[Image:2arw.gif|left|200px]]<br /><applet load="2arw" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''<br /> | '''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ARW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2ARW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: fibronectin-type iii like]] | [[Category: fibronectin-type iii like]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:14:47 2008'' |
Revision as of 15:14, 15 February 2008
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The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
Overview
The members of the interleukin-6-type family of cytokines interact with, receptors that have a modular structure and are built of several, immunoglobulin-like and fibronectin type III-like domains. These receptors, have a characteristic cytokine receptor homology region consisting of two, fibronectin type III-like domains defined by a set of four conserved, cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On, target cells, interleukin-6 (IL-6) initially binds to its cognate, alpha-receptor and subsequently to a homodimer of the signal transducer, receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular, domains. The N-terminal immunoglobulin-like domain is not involved in, ligand binding, whereas the third membrane-proximal fibronectin-like, domain (IL-6R-D3) accounts for more than 90% of the binding energy to, IL-6. Here, we present the solution structure of the IL-6R-D3 domain, solved by multidimensional heteronuclear NMR spectroscopy.
About this Structure
2ARW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794
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