Factor VIII
From Proteopedia
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[[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for [[Factor IX|factor IXa]]. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of human Factor VIII ([[2r7e]]). | [[Factor VIII]] (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for [[Factor IX|factor IXa]]. The images at the left and at the right correspond to one representative FVIII, ''i.e.'' the crystal structure of human Factor VIII ([[2r7e]]). | ||
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| + | ===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII=== | ||
| + | The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | ||
| + | <scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | ||
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Revision as of 12:12, 3 June 2012
Image:2r7e.png
Crystal Structure of human Factor VIII, 2r7e
Factor VIII (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, i.e. the crystal structure of human Factor VIII (2r7e).
Contents |
3D Structures of Factor VIII
2r7e, 3cdz – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
