2b1p
From Proteopedia
(New page: 200px<br /> <applet load="2b1p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b1p, resolution 1.900Å" /> '''inhibitor complex ...) |
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caption="2b1p, resolution 1.900Å" /> | caption="2b1p, resolution 1.900Å" /> | ||
'''inhibitor complex of JNK3'''<br /> | '''inhibitor complex of JNK3'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2B1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, AIZ and BME as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 2B1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=AIZ:'>AIZ</scene> and <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1P OCA]. |
==Reference== | ==Reference== | ||
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[[Category: kinase inhibitor]] | [[Category: kinase inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:15:22 2008'' |
Revision as of 15:15, 15 February 2008
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inhibitor complex of JNK3
Contents |
Overview
The structure-based design and synthesis of a new series of c-Jun, N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha, is reported. The novel series of substituted 6-anilinoindazoles were, designed based on a combination of hits from high throughput screening and, X-ray crystal structure information of the compounds crystallized into the, JNK3 ATP binding active site.
Disease
Known diseases associated with this structure: Epileptic encephalopathy, Lennox-Gastaut type OMIM:[602897]
About this Structure
2B1P is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3., Swahn BM, Huerta F, Kallin E, Malmstrom J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L, Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. PMID:16140012
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