2bdy

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(New page: 200px<br /> <applet load="2bdy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bdy, resolution 1.610&Aring;" /> '''thrombin in comple...)
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[[Image:2bdy.gif|left|200px]]<br />
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[[Image:2bdy.jpg|left|200px]]<br /><applet load="2bdy" size="350" color="white" frame="true" align="right" spinBox="true"
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<applet load="2bdy" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="2bdy, resolution 1.610&Aring;" />
caption="2bdy, resolution 1.610&Aring;" />
'''thrombin in complex with inhibitor'''<br />
'''thrombin in complex with inhibitor'''<br />
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==About this Structure==
==About this Structure==
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2BDY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA and UNB as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BDY OCA].
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2BDY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=UNB:'>UNB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDY OCA].
==Reference==
==Reference==
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[[Category: thrombin]]
[[Category: thrombin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:01:36 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:16:04 2008''

Revision as of 15:16, 15 February 2008

Image:2bdy.jpg

2bdy, resolution 1.610Å

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thrombin in complex with inhibitor

Contents

Overview

Prototypical thrombin inhibitors were synthesized based on a, trisubstituted phenol as a core motif. A naphthylsulfonamide analogue, showed excellent antithrombin activity. An X-ray co-crystal structure, showed the expected interactions.

Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

2BDY is a Protein complex structure of sequences from Homo sapiens with and as ligands. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.

Reference

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure., Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellstrom O, Xue Y, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15. PMID:16290930

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