2bid
From Proteopedia
(New page: 200px<br /> <applet load="2bid" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bid" /> '''HUMAN PRO-APOPTOTIC PROTEIN BID'''<br /> =...) |
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| - | [[Image:2bid. | + | [[Image:2bid.jpg|left|200px]]<br /><applet load="2bid" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''HUMAN PRO-APOPTOTIC PROTEIN BID'''<br /> | '''HUMAN PRO-APOPTOTIC PROTEIN BID'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2BID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BID OCA]. |
==Reference== | ==Reference== | ||
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[[Category: programmed cell death]] | [[Category: programmed cell death]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:16:20 2008'' |
Revision as of 15:16, 15 February 2008
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HUMAN PRO-APOPTOTIC PROTEIN BID
Overview
We report the solution structure of BID, an intracellular cross-talk agent, that can amplify FAS/TNF apoptotic signal through the mitochondria death, pathway after Caspase 8 cleavage. BID contains eight alpha helices where, two central hydrophobic helices are surrounded by six amphipathic ones., The fold resembles poreforming bacterial toxins and shows similarity to, BCL-XL although sequence homology to BCL-XL is limited to the 16-residue, BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by, aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex., Additionally, we show that the overall structure of BID is preserved after, cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent, and -independent modes of action in inducing mitochondrial damage.
About this Structure
2BID is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of BID, an intracellular amplifier of apoptotic signaling., Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G, Cell. 1999 Mar 5;96(5):615-24. PMID:10089877
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