1qls
From Proteopedia
(New page: 200px<br /> <applet load="1qls" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qls, resolution 2.3Å" /> '''S100C (S100A11),OR C...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1QLS is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]] with CA and ACE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QLS OCA]]. | + | 1QLS is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]] with CA and ACE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QLS OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: s100 family]] | [[Category: s100 family]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:21:39 2007'' |
Revision as of 11:16, 30 October 2007
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S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS
Overview
Background: S100C (S100A11) is a member of the S100 calcium-binding, protein family, the function of which is not yet entirely clear, but may, include cytoskeleton assembly and dynamics. S100 proteins consist of two, EF-hand calcium-binding motifs, connected by a flexible loop. Like several, other members of the family, S100C forms a homodimer. A number of S100, proteins form complexes with annexins, another family of calcium-binding, proteins that also bind to phospholipids. Structural studies have been, undertaken to understand the basis of these interactions. Results: We have, solved the crystal structure of a complex of calcium-loaded S100C with a, synthetic peptide that corresponds to the first 14 residues of the annexin, I N terminus at 2.3 A resolution. We find a stoichiometry of ... [(full description)]
About this Structure
1QLS is a [Protein complex] structure of sequences from [Homo sapiens] and [Sus scrofa] with CA and ACE as [ligands]. Structure known Active Sites: CA1 and CA2. Full crystallographic information is available from [OCA].
Reference
Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I., Rety S, Osterloh D, Arie JP, Tabaries S, Seeman J, Russo-Marie F, Gerke V, Lewit-Bentley A, Structure. 2000 Feb 15;8(2):175-84. PMID:10673436
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